Our research group develops and applies mass spectrometry and the tools of proteomics to problems in clinical research. We are especially interested in the discovery and validation of biomarkers of disease and towards this end we work as a part of an interdisciplinary team that integrates basic scientists and clinical researchers.

Recently Accepted and Published Works

1. Duncan MW, Gale PJ, Yergey AL. Quantification. In The Encyclopedia of Mass Spectrometry. Vol. 3. Biological Applications. Part B. Elsevier. Eds. R. Caprioli & M. Gross. 2006:3:341-347.
2. Hunsucker SW, Duncan MW. Is protein overlap in two-dimensional gels a serious practical problem? Proteomics. 2006:6(5):1374-1375.
3. Duncan, MW, Gale, JP, Yergey AL. The Principles of Quantitative Mass Spectrometry. Rockpool Productions, 2006, 142 pages. ISBN 0-9786058-0-2
4. Brown LM, Helmke SM, Hunsucker SW, Netea-Maier RT, Chiang SA, Heinz DE, Shroyer KR, Duncan MW, Haugen BR. Quantitative and qualitative differences in protein expression between papillary thyroid carcinoma and normal thyroid tissue. Mol Carcinogen. 2006:45(8):613-26.
5. Duncan MW, Marini AM. Debating the cause of a neurological disorder. Science 2006:313(5794):1737.
6. Duncan MW, Hunsucker SW. Comments on standards in proteomics and the concept of fitness-for-purpose. Proteomics. 2006:6(S2):45-47.
7. Duncan MW, Helmke M. Measurement of the NO metabolites, nitrite and nitrate, in human biological fluids by GC-MS. J Chromatogr B 2006, Oct 26 [Epub ahead of print].
8. Duncan, MW. Proteomics and its Fifteen Minutes. (Editorial) Exp Biol Med (Maywood). 2007 Apr;232(4):471-2.
9. Solomon B, Helfrich B, Zeng C, Chansky K, Nakajima E, Gazdar AF, Gandara D, Franklin WA, Hirsch FR, Duncan MW, Bunn Jr. PA, Hunsucker SW. Identification of putative biomarkers of gefitinib sensitivity in non-small cell lung cancer using difference gel electrophoresis (DIGE). J. Nat. Cancer Inst. (Accepted for publication)
10. Kumar G, Smith QR, Hokari M, Parepally J, Duncan MW. Brain uptake, pharmacokinetics and tissue distribution in the rat of neurotoxic N-butylbenzenesulfonamide. Toxicol Sci. 2007 Mar 15; [Epub ahead of print]
11. McDermott RA, Porterfield HS, Mezayen RE, Burks AW, Pons L, Schlichting DG, Solomon B, Redzic JS, Harbeck RJ, Duncan MW, Hansen KC, Dreskin SC. Contribution of Ara h 2 to peanut-specific, immunoglobulin E-mediated, cell activation. Clin Exp Allergy. 2007 May;37(5):752-63.
12. Raj JU, Aliferis C, Caprioli RM, Cowley Jr AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. Genomics and Proteomics of Lung Disease: Conference Summary. Am J Physiol Lung Cell Mol Physiol. 2007 Apr 27; [Epub ahead of print]
13. Taguchi F, Solomon B, Gregorc V, Roder H, Gray R, Kasahara K, Nishio M, Brahmer J, Spreafico A, Ludovini V, Massion PP, Dziadziuszko R, Schiller J, Grigorieva J, Tsypin M, Hunsucker SW, Caprioli R, Duncan MW, Hirsch FR, Bunn Jr PA, Carbone DP. Mass Spectrometry to Classify Non ­ Small-Cell Lung Cancer Patients for Clinical Outcome After Treatment With Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Multicohort Cross-Institutional Study.
14. Hunsucker SW, Accurso FJ, Duncan MW. Proteomics in Pediatric Research and Practice. Adv. Peds. 2007.
15. Chace DH, Barr JR, Duncan MW, Matern D, Morris MR, Palmer-Toy DE, Rockwood AL, Suizdak G, Urbani A, Yergey AL, Chan YM. Mass Spectrometry in the Clinical Laboratory: General Principles and Guidance; Proposed Guideline. Clinical and Laboratory Standards Institute. 2007:27(3).
16. Duncan MW, Solomon B. Proteomics of seminal fluid. In “Proteomics of Human Body Fluids: Principles, Methods and Applications” Ed. Visith Thongboonkerd, Humana Press 2007. In press.
17. Duncan MW and Thompson H. Proteomics of Semen and its Constituents. Proteomics, 2007. (In press)